Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas

@article{Chung2012ExploringAS,
  title={Exploring a sulfone linker utilizing trimethyl aluminum as a cleavage reagent: solid-phase synthesis of sulfonamides and ureas},
  author={Tsai-Wen Chung and C. Chen and Chu-Chung Lin and H. Wu and C. Sun and W. Chung},
  journal={Molecular Diversity},
  year={2012},
  volume={16},
  pages={463-476}
}
A novel and efficient cleavage reagent, trimethyl aluminum, for traceless sulfinate-functionalized resin has been developed. The synthesis of sulfonamide and urea derivatives via a traceless solid-phase sulfone linker strategy through six synthetic steps comprising utilization of trimethyl aluminum as a novel cleavage reagent was also established. An insight of the plausible mechanism of the cleavage reaction was discussed.Graphical Abstract 

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