Exploring Treatment by Covariate Interactions Using Subgroup Analysis and Meta-Regression in Cochrane Reviews: A Review of Recent Practice

@inproceedings{Donegan2015ExploringTB,
  title={Exploring Treatment by Covariate Interactions Using Subgroup Analysis and Meta-Regression in Cochrane Reviews: A Review of Recent Practice},
  author={Sarah Donegan and Lisa Williams and S. A. D. Dias and Catrin Tudur-Smith and Nicky J Welton and Asad U. Khan},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Treatment by covariate interactions can be explored in reviews using interaction analyses (e.g., subgroup analysis). Such analyses can provide information on how the covariate modifies the treatment effect and is an important methodological approach for personalising medicine. Guidance exists regarding how to apply such analyses but little is known about whether authors follow the guidance. METHODS Using published recommendations, we developed criteria to assess how well… CONTINUE READING
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