Exploring Mycobacterium avium inhibition by macrocyclic compounds.

Derivatives of synthetic macrocyclic compounds, MCC, 12- and 14-membered tetraazamacrocycles with N-pendant arms, such as N-methyl (Mepy14), N-acetate (DOTA, TETA and ac3py14) and N-methylphosphonate (DOTP) groups, were investigated in terms of their in vitro activity against Mycobacterium avium and for intracellular clearance, using the murine macrophage… CONTINUE READING