Exploring Memory Representations with Activity-Based Genetics.

@article{Mayford2015ExploringMR,
  title={Exploring Memory Representations with Activity-Based Genetics.},
  author={Mark R. Mayford and Leon G Reijmers},
  journal={Cold Spring Harbor perspectives in biology},
  year={2015},
  volume={8 3},
  pages={
          a021832
        }
}
The brain is thought to represent specific memories through the activity of sparse and distributed neural ensembles. In this review, we examine the use of immediate early genes (IEGs), genes that are induced by neural activity, to specifically identify and genetically modify neurons activated naturally by environmental experience. Recent studies using this approach have identified cellular and molecular changes specific to neurons activated during learning relative to their inactive neighbors… CONTINUE READING
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