Exploring Cell Tropism as a Possible Contributor to Influenza Infection Severity

@inproceedings{Dobrovolny2010ExploringCT,
  title={Exploring Cell Tropism as a Possible Contributor to Influenza Infection Severity},
  author={Hana M. Dobrovolny and Marc J. Baron and R. Gieschke and Brian E. Davies and Nelson L. Jumbe and Catherine A A Beauchemin},
  booktitle={PloS one},
  year={2010}
}
Several mechanisms have been proposed to account for the marked increase in severity of human infections with avian compared to human influenza strains, including increased cytokine expression, poor immune response, and differences in target cell receptor affinity. Here, the potential effect of target cell tropism on disease severity is studied using a mathematical model for in-host influenza viral infection in a cell population consisting of two different cell types. The two cell types differ… CONTINUE READING

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SHOWING 1-10 OF 63 REFERENCES

Differential susceptibility of different cell lines to swine-origin influenza A H1N1, seasonal human influenza A H1N1, and avian influenza A H5N1 viruses.

  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2009
VIEW 1 EXCERPT

Emergence of a novel swine - origin influenza A ( H 1 N 1 ) virus in humans

WR Gallaher
  • N Engl J Med
  • 2009