Explorer M 2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

@inproceedings{Morgana2013ExplorerM2,
  title={Explorer M 2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation},
  author={Hugh P. Morgana and O FrancisJ. and Reillya and Martin A. Weara and O J.Robert and Neillb and Linda A. Fothergill-Gilmorea and Ted Huppb and Malcolm D. Walkinshawa},
  year={2013}
}
  • Hugh P. Morgana, O FrancisJ., +6 authors Malcolm D. Walkinshawa
  • Published 2013
We show that the M2 isoform of pyruvate kinase (M2PYK) exists in equilibrium between monomers and tetramers regulated by allosteric binding of naturally occurring small-molecule metabolites. Phenylalanine stabilizes an inactive T-state tetrameric conformer and inhibits M2PYKwith an IC50 value of 0.24mM,whereas thyroid hormone (triiodo-L-thyronine, T3) stabilizes an inactive monomeric form of M2PYK with an IC50 of 78 nM. The allosteric activator fructose-1,6-bisphosphate [F16BP, AC50… CONTINUE READING

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