Explorer Competition between Primary Nucleation and Autocatalysis in Amyloid Fibril Self-Assembly

Abstract

Kinetic measurements of the self-assembly of proteins into amyloid fibrils are often used to make inferences about molecular mechanisms. In particular, the lag time — the quiescent period before aggregates are detected — is often found to scale with the protein concentration as a power law, whose exponent has been used to infer the presence or absence of… (More)

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