Explorer 11-hydroxysteroid dehydrogenase type 1 , brain atrophy and cognitive decline

Abstract

Excess cortisol levels are linked with brain atrophy and cognitive decline in older people. 11ßhydroxysteroid dehydrogenase type 1 (11ß-HSD1) potently amplifies intracellular glucocorticoid action by converting inert cortisone to active cortisol, but any causal importance in brain ageing is unexplored. We tested the hypotheses that higher systemic 11ß-HSD1… (More)

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