ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies

@article{Mutsaerts2020ExploreASLAI,
  title={ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies},
  author={Henri Jmm Mutsaerts and Jan Petr and Paul Groot and Pieter Vandemaele and Silvia Ingala and Andrew Donald Robertson and Lena V{\'a}clavů and Inge Groote and Hugo J. Kuijf and Fernando O. Zelaya and Owen G. O'Daly and Saima Hilal and Alle Meije Wink and Ilse MJ Kant and Matthan W. A. Caan and Catherine A. Morgan and Jeroen de Bresser and Elisabeth Lysvik and Anouk Schrantee and Astrid Bj{\o}rnebekk and Patricia Clement and Zahra Shirzadi and Joost P. A. Kuijer and Udunna C. Anazodo and Dasja Pajkrt and Edo Richard and Reinoud P. H. Bokkers and Liesbeth Reneman and Mario Masellis and Matthias G{\"u}nther and Bradley J. MacIntosh and Eric Achten and Michael A. Chappell and Matthias J. P. van Osch and Xavier Golay and David L. Thomas and Enrico de Vita and Atle Bj{\o}rnerud and Aart J. Nederveen and Jeroen Hendrikse and Iris Asllani and Frederik Barkhof},
  journal={NeuroImage},
  year={2020},
  volume={219}
}
A Beginner's Guide to Arterial Spin Labeling (ASL) Image Processing
TLDR
An introduction of the physiology and MRI technique behind ASL, and how they interact with the image processing, is presented and an overview of processing pipelines is presented to help develop an understanding of which processing steps to check for their own analyses.
Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling
TLDR
Arterial spin-labeling imaging is reproducible at both field strengths, and the reproducibility is not significantly correlated with age, and 3T tolerates more acquisition parameter variations and allows more extensive optimizations so that 3D and 2D acquisitions can be compared.
CAT – A Computational Anatomy Toolbox for the Analysis of Structural MRI Data
TLDR
The Computational Anatomy Toolbox (CAT) is introduced - a powerful suite of tools for morphometric analyses with an intuitive graphical user interface, but also usable as a shell script.
Arterial spin labeling: Adaptive thresholding for epileptogenic zone detection in MRI-negative epilepsy
TLDR
The ASL can be easily incorporated to the standard presurgical MR protocol and it provides an additional benefit in EZ localization, and an image processing method to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side is developed.
Epileptogenic zone detection in MRI negative epilepsy using adaptive thresholding of arterial spin labeling data
TLDR
An image processing method is developed to detect the EZ as an area with hypoperfusion relative to the contralateral unaffected side, using subject-specific thresholding of the asymmetry index in ASL images, which can be easily incorporated into the standard presurgical MR protocol and provides an additional benefit in EZ localization.
GliMR: Cross-Border Collaborations to Promote Advanced MRI Biomarkers for Glioma
TLDR
The network “Glioma MR Imaging 2.0” (GliMR) aims to build a pan-European and multidisciplinary network of experts and accelerate the use of advanced MRI in glioma beyond the current “state-of-the-art” inglioma imaging.
Workflow for automatic renal perfusion quantification using ASL‐MRI and machine learning
TLDR
A fully automatic workflow for renal cortex perfusion quantification by including machine learning‐based segmentation of the cortex to obtain cortical renal blood flow (RBF).
From research to clinical practice: a European neuroradiological survey on quantitative advanced MRI implementation
TLDR
Beyond the aspect of readiness for clinical use, better availability of support and a wider dissemination of guidelines could catalyse a broader implementation of qMRI techniques across Europe.
...
...

References

SHOWING 1-10 OF 301 REFERENCES
Arterial Spin-Labeling in Routine Clinical Practice, Part 1: Technique and Artifacts
TLDR
The experience with a heterogeneous collection of ASL perfusion cases with an emphasis on methodology and common artifacts encountered with the technique is described to help avoid pitfalls in the interpretation of CBF maps.
Consensus-based technical recommendations for clinical translation of renal ASL MRI
TLDR
Recommendations for the acquisition, processing and analysis of renal ASL data in the human kidney at 1.5 T and 3 T field strengths that can promote standardization of renal perfusion measurements and facilitate the comparability of results across scanners and in multi-centre clinical studies are developed.
Inter-Vendor Reproducibility of Pseudo-Continuous Arterial Spin Labeling at 3 Tesla
TLDR
These results show that total GM CBF-values can be exchanged between vendors, and encourage further standardization of ASL implementation among vendors.
Separation of macrovascular signal in multi‐inversion time arterial spin labelling MRI
TLDR
It is shown by comparing data with and without flow suppression, and by comparing the intravascular contribution in GRASE ASL data to MR angiographic images, that the model‐fitting approach can provide a viable alternative to flow suppression in ASL where suppression is either not feasible or not desirable.
Intra- and Multicenter Reproducibility of Pulsed, Continuous and Pseudo-Continuous Arterial Spin Labeling Methods for Measuring Cerebral Perfusion
  • S. Gevers, M. V. van Osch, A. Nederveen
  • Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2011
TLDR
One could consider the use of reference values in clinical routine, with whole-brain p-CASL perfusion varying < 20% over repeated measurements within the same individuals considered to be normal, on the basis of the results of this study.
...
...