Exploratory analysis of activation of PTEN-PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM).

@article{Cedrs2012ExploratoryAO,
  title={Exploratory analysis of activation of PTEN-PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM).},
  author={Susana Cedr{\'e}s and M Angeles Montero and Pablo Mart{\'i}nez and Alejandro Mart{\'i}nez and V{\'i}ctor Rodr{\'i}guez-Freixin{\'o}s and Davis Y Torrejon and Alfredo Gabaldon and Michelle P Salcedo and Santiago Ramon Y Cajal and E Felip},
  journal={Lung cancer},
  year={2012},
  volume={77 1},
  pages={192-8}
}
BACKGROUND Malignant pleural mesothelioma (MPM) is a highly aggressive neoplasm with elevated AKT/mTOR activity. We aimed to identify the expression and phosphorylation status of PTEN, PI3K and downstream signaling in MPM. PATIENTS AND METHODS Thirty consecutive MPM patients were identified. Clinical data analyzed: sex, age, histology, performance status (PS), white blood count, and neutrophil-lymphocyte ratio (NLR). Paraffin-embedded biopsies were used for immunohistochemical analysis… CONTINUE READING
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