Exploratory Literature Meta-Analysis to Characterize the Relationship Between Early and Longer Term Body Weight Loss for Antiobesity Compounds.

@article{Plock2017ExploratoryLM,
  title={Exploratory Literature Meta-Analysis to Characterize the Relationship Between Early and Longer Term Body Weight Loss for Antiobesity Compounds.},
  author={Nele Plock and Leon Bax and Douglas H. K. Lee and Deborah DeManno and Gezim Lahu and Marc Pfister},
  journal={Journal of clinical pharmacology},
  year={2017},
  volume={57 1},
  pages={52-63}
}
The presented analysis was performed to characterize the relationship between treatment-related early (week 4) and longer term (3-6 months) weight loss to understand the potential utility of 4-week proof-of-mechanism studies in the early decision-making process during clinical development of new antiobesity compounds. A regression-based meta-analysis was performed leveraging publically available clinical outcomes data to (1) characterize the within-trial relationship between treatment-related… CONTINUE READING
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