Exploratory Experiments on the Chemistry of the “Glyoxylate Scenario”: Formation of Ketosugars from Dihydroxyfumarate

@inproceedings{Sagi2012ExploratoryEO,
  title={Exploratory Experiments
on the Chemistry of the “Glyoxylate
Scenario”: Formation of Ketosugars from Dihydroxyfumarate},
  author={Vasudeva Naidu Sagi and Venkateshwarlu Punna and Fang Hu and Geeta Meher and Ramanarayanan Krishnamurthy},
  booktitle={Journal of the American Chemical Society},
  year={2012}
}
In the context of a "glyoxylate scenario" of primordial metabolism, the reactions of dihydroxyfumarate (DHF) with reactive small molecule aldehydes (e.g., glyoxylate, formaldehyde, glycolaldehyde, and glyceraldehyde) in water were investigated and shown to form dihydroxyacetone, tetrulose, and the two pentuloses, with almost quantitative conversion. The practically clean and selective formation of ketoses in these reactions, with no detectable admixture of aldoses, stands in stark contrast to… CONTINUE READING

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