Exploration of the use of an acylsulfonamide safety-catch linker for the polymer-supported synthesis of hyaluronic acid oligosaccharides.

@article{Paz2010ExplorationOT,
  title={Exploration of the use of an acylsulfonamide safety-catch linker for the polymer-supported synthesis of hyaluronic acid oligosaccharides.},
  author={J. D. de Paz and M. Mar Kayser and Giuseppe Macchione and P. Nieto},
  journal={Carbohydrate research},
  year={2010},
  volume={345 5},
  pages={
          565-71
        }
}
The synthesis of hyaluronic acid oligosaccharides on polyethylene glycol (PEG) using an acylsulfonamide linker has been explored. Hyaluronic acid is a challenging synthetic target that usually involves the condensation of highly disarmed glucuronic acid building blocks. Amine-ended PEG monomethyl ether was efficiently functionalized with a hydroxyl-terminated acylsulfonamide linker. Suitably protected D-glucosamine (GlcN) and D-glucuronic acid (GlcA) monosaccharide building blocks were coupled… Expand
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