Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.

Abstract

Translational arrest peptides (APs) are short stretches of polypeptides that induce translational stalling when synthesized on a ribosome. Mechanical pulling forces acting on the nascent chain can weaken or even abolish stalling. APs can therefore be used as in vivo force sensors, making it possible to measure the forces that act on a nascent chain during… (More)
DOI: 10.1074/jbc.M115.641555

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