Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors.


The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S2 and S3 subsites with a series of carbamate derivatized norleucine aldehydes substituted at the P2 and P3 positions afforded analogs with cathepsin K IC50s between 600 nM and 130 pM. 


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.