Exploration of interactions of ‘blood-nano interface’ of carbon-based nanomaterials for biomedical applications

  title={Exploration of interactions of ‘blood-nano interface’ of carbon-based nanomaterials for biomedical applications},
  author={Vishal Singh and A. Basu and Pingali M. Shivapriya and Pritish Kumar Varadwaj and Sintu Samanta and Amaresh Sahoo},
  journal={Journal of Materials Research},
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2 Citations
Recent development of autonomously driven micro/nanobots for efficient treatment of polluted water.
It is deemed that nanobots might be a smart choice for using these as the new generation devices for treating industrial effluents before discharging it in the water bodies, which is a major concern for human health and the environment.


Interaction of graphene nanoribbons with components of the blood vascular system
It is indicated that low concentrations of O-GNR-PEG-DSPE are relatively nontoxic to the hematological components, and could be employed for diagnostic and therapeutic applications especially for diseases of the circulatory system.
Graphene-based nanomaterials for drug delivery and tissue engineering.
  • Sumit Goenka, V. Sant, S. Sant
  • Materials Science, Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2014
This article presents a comprehensive review of various types and properties of graphene family nanomaterials and highlights how these properties are being exploited for drug delivery and tissue engineering applications.
Thrombus inducing property of atomically thin graphene oxide sheets.
It is reported for the first time that atomically thin GO sheets elicited strong aggregatory response in platelets through activation of Src kinases and release of calcium from intracellular stores, raising concern on putative biomedical applications of GO in the form of diagnostic and therapeutic tools.
The hemocompatibility of oxidized diamond nanocrystals for biomedical applications
It is demonstrated that 35-nm NDs after covalent conjugation with polyarginine are useful as a drug delivery vehicle of heparin for prolonged anticoagulation treatment and lays a solid foundation for further therapeutic applications of NDs in biomedicine.
Designing the nanoparticle-biomolecule interface for "targeting and therapeutic delivery".
To transfer the remarkable possibilities of nanoscale interactions in biology into therapeutics one may need a more focused and dedicated approach to the understanding of the in situ (in vivo) interface between engineered nanomaedicines and their targets.
Functionalization of graphene oxide generates a unique interface for selective serum protein interactions.
It is demonstrated that nGO-PEG may serve to help eliminate the C3a/C3a(des-Arg) induced by other nanomaterials such as as-made GO, indicating a new strategy to modulate the immune responses evoked by one Nanomaterial through the addition of another type of nanommaterial.
Amine-modified graphene: thrombo-protective safer alternative to graphene oxide for biomedical applications.
It is concluded that G-NH(2) is not endowed with thrombotoxic property unlike other commonly investigated graphene derivatives and is thus potentially safe for in vivo biomedical applications.
Nanodiamonds for Medical Applications: Interaction with Blood in Vitro and in Vivo
It was found that adsorption of a low concentration of ND does not affect the oxygenation state of red blood cells (RBC) and the results further confirm nanodiamonds’ safety in organisms, as well as the possibility of their application without complicating the blood’s physiological conditions.
Interactions of nanomaterials with the immune system.
Interactions of nonbiodegradable, persistent NPs with the immune system are given, including key factors that shape such interactions, cell-specific responses, allergy and immune-sensitive respiratory disorders.
Evidencing the mask effect of graphene oxide: a comparative study on primary human and murine phagocytic cells.
The more the lateral dimensions of GO were reduced, the higher were the cellular internalization and the effects on cellular functionality, and a particular interaction of GO flakes with the cellular membrane was observed, possibly accounting for the following impact on cellular parameters.