Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort

@inproceedings{Taylor2016ExplorationOA,
  title={Exploration of a Polygenic Risk Score for Alcohol Consumption: A Longitudinal Analysis from the ALSPAC Cohort},
  author={Michelle Taylor and Andrew J Simpkin and Philip C. Haycock and Frank Dudbridge and Luisa Zuccolo},
  booktitle={PloS one},
  year={2016}
}
BACKGROUND Uncertainty remains about the true extent by which alcohol consumption causes a number of health outcomes. Genetic variants, or combinations of variants built into a polygenic risk score (PGRS), can be used in an instrumental variable framework to assess causality between a phenotype and disease outcome of interest, a method known as Mendelian randomisation (MR). We aimed to identify genetic variants involved in the aetiology of alcohol consumption, and develop a PGRS for alcohol… CONTINUE READING
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