Exploration of Molecular Targets in the Development of New Therapeutics Aimed at Overcoming Multidrug Resistance.

Abstract

Multidrug resistance (MDR) in cancer is a major problem in clinical settings: MDR correlates with a patient's poor prognosis and decreased quality of life. Recently, MDR was found to be involved in various signal pathways, so the inhibition of signal molecules by molecular targeting drugs may help overcome MDR. In addition, the acquisition of MDR is shown… (More)
DOI: 10.1248/yakushi.16-00229-5

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