Exploration of G-quadruplex function in c-Myb gene and its transcriptional regulation by topotecan.

Abstract

Our bioinformatics research shows that there are four G-rich sequences (S1-S4) in the upstream region of the transcription start site of c-Myb gene, and we have proved that these sequences have the ability to form G-quadruplex structures. This work mainly focuses on G-quadruplex function, recognition and transcription regulation in c-Myb gene, revealing a… (More)
DOI: 10.1016/j.ijbiomac.2017.10.010

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