Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions.

  title={Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions.},
  author={Changsheng Zhang and Byron R Griffith and Qiang Fu and Christoph Albermann and Xun Fu and I Y Lee and Lingjun Li and Jon S Thorson},
  volume={313 5791},
Glycosyltransferases (GTs), an essential class of ubiquitous enzymes, are generally perceived as unidirectional catalysts. In contrast, we report that four glycosyltransferases from two distinct natural product biosynthetic pathways-calicheamicin and vancomycin-readily catalyze reversible reactions, allowing sugars and aglycons to be exchanged with ease. As proof of the broader applicability of these new reactions, more than 70 differentially glycosylated calicheamicin and vancomycin variants… CONTINUE READING

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