Exploiting the p53 pathway for the diagnosis and therapy of human cancer.

  title={Exploiting the p53 pathway for the diagnosis and therapy of human cancer.},
  author={David Philip Lane},
  journal={Cold Spring Harbor symposia on quantitative biology},
After 26 years of research and the publication of 38,000 papers, our knowledge of the p53 human tumor suppressor protein is impressive. Over half of all human cancers have mutations in the p53 gene, and the p53 pathway in animal models dramatically regulates the cellular response to ionizing radiation and chemotherapeutic drugs. The ability to translate this knowledge to patient benefit is, however, still in its infancy. The many approaches to determining the status of the p53 pathway in human… CONTINUE READING

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