Exploiting the hypoxia sensitive non-coding genome for organ-specific physiologic reprogramming.

@article{Bischof2016ExploitingTH,
  title={Exploiting the hypoxia sensitive non-coding genome for organ-specific physiologic reprogramming.},
  author={Corinne Bischof and Jaya Krishnan},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1863 7 Pt B},
  pages={1782-90}
}
In this review we highlight the role of non-coding RNAs in the development and progression of cardiac pathology and explore the possibility of disease-associated RNAs serving as targets for cardiac-directed therapeutics. Contextually, we focus on the role of stress-induced hypoxia as a driver of disease development and progression through activation of hypoxia inducible factor 1α (HIF1α) and explore mechanisms underlying HIFα function as an enforcer of cardiac pathology through direct… CONTINUE READING