Exploiting the Metal-Chelating Properties of the Drug Cargo for In Vivo Positron Emission Tomography Imaging of Liposomal Nanomedicines

@inproceedings{Edmonds2016ExploitingTM,
  title={Exploiting
the Metal-Chelating Properties of the Drug
Cargo for In Vivo Positron Emission Tomography Imaging
of Liposomal Nanomedicines},
  author={Scott Edmonds and Alessia Volpe and Hilary Shmeeda and Ana Caterina Parente-Pereira and Riya Radia and Julia Bagu{\~n}a-Torres and Istv{\'a}n Szanda and Gregory W. Severin and Lefteris Livieratos and Philip J Blower and John Maher and G O Fruhwirth and Alberto Gabizon and Rafael T M de Rosales},
  booktitle={ACS nano},
  year={2016}
}
The clinical value of current and future nanomedicines can be improved by introducing patient selection strategies based on noninvasive sensitive whole-body imaging techniques such as positron emission tomography (PET). Thus, a broad method to radiolabel and track preformed nanomedicines such as liposomal drugs with PET radionuclides will have a wide impact in nanomedicine. Here, we introduce a simple and efficient PET radiolabeling method that exploits the metal-chelating properties of certain… CONTINUE READING
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