Exploiting our knowledge of NF-kappaB signaling for the treatment of mammary cancer.

@article{Haffner2006ExploitingOK,
  title={Exploiting our knowledge of NF-kappaB signaling for the treatment of mammary cancer.},
  author={Michael C. Haffner and Chiara Berlato and Wolfgang Doppler},
  journal={Journal of mammary gland biology and neoplasia},
  year={2006},
  volume={11 1},
  pages={63-73}
}
Nuclear Factor-kappaB (NF-kappaB) has been implicated in the lobuloalveolar development of the mammary gland. In breast cancer its activation has been linked to tumor progression via stimulation of cell proliferation, pro-survival, and angiogenesis pathways and metastasis. Whether NF-kappaB activation in the immune system influences mammary cancer remains unclear. In addition to the constitutive activation frequently found in mammary carcinoma tissue, radio- and chemotherapeutic agents used in… CONTINUE READING

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