Exploiting hidden symmetry in natural products: total syntheses of amphidinolides C and F.

Abstract

The total synthesis of amphidinolide C and a second-generation synthesis of amphidinolide F have been accomplished through the use of a common intermediate to access both the C1-C8 and the C18-C25 sections. The development of a Ag-catalyzed cyclization of a propargyl benzoate diol is described to access both trans-tetrahydrofuran rings. The evolution of a… (More)
DOI: 10.1021/ja404796n

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