Exploiting extracellular matrix-stem cell interactions: a review of natural materials for therapeutic muscle regeneration.

@article{Kuraitis2012ExploitingEM,
  title={Exploiting extracellular matrix-stem cell interactions: a review of natural materials for therapeutic muscle regeneration.},
  author={Drew Kuraitis and C{\'e}line Giordano and Marc A Ruel and Antonio Musar{\`o} and Erik J. Suuronen},
  journal={Biomaterials},
  year={2012},
  volume={33 2},
  pages={428-43}
}
Myopathies of skeletal muscle are prevalent diseases worldwide. To address this, regenerative therapies are being developed to restore perfusion to ischemic muscle and to reverse muscle wasting. There are adult stem cell populations that inherently possess these therapeutic properties; however, cell transplantation trials in the clinic have shown modest results at best, being limited by poor cell persistence and viability post-transplantation, and by cell relocation to non-target sites. Many… CONTINUE READING

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