Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer

@article{EnriquezNavas2016ExploitingEP,
  title={Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer},
  author={Pedro M. Enriquez-Navas and Yoonseok Kam and Tuhin Das and Sabrina Hassan and Ariosto Siqueira Silva and Parastou Foroutan and Epifanio Ruiz and G Valencia Mart{\'i}nez and Susan E. Minton and Robert James Gillies and Robert A. Gatenby},
  journal={Science Translational Medicine},
  year={2016},
  volume={8},
  pages={327ra24-327ra24}
}
Conventional cancer treatment strategies assume that maximum patient benefit is achieved through maximum killing of tumor cells. However, by eliminating the therapy-sensitive population, this strategy accelerates emergence of resistant clones that proliferate unopposed by competitors—an evolutionary phenomenon termed “competitive release.” We present an evolution-guided treatment strategy designed to maintain a stable population of chemosensitive cells that limit proliferation of resistant… CONTINUE READING
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