Exploiting current understanding of antibiotic action for discovery of new drugs.

@article{Chopra2002ExploitingCU,
  title={Exploiting current understanding of antibiotic action for discovery of new drugs.},
  author={I. Chopra and Lars Hesse and Alex J O'Neill},
  journal={Journal of applied microbiology},
  year={2002},
  volume={92 Suppl},
  pages={4S-15S}
}
The introduction of antibiotics for the chemotherapy of bacterial infections has been one of the most important medical achievements of the past 50 years. However, the emergence of bacterial resistance to antibiotics undermines the therapeutic utility of existing agents, creating a requirement for the discovery of new antibacterial drugs. Several drug discovery strategies have emerged, including incremental improvements to existing antibiotics by chemical manipulation and the search for novel… CONTINUE READING

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