Exploiting cancer cell cycling for selective protection of normal cells.

@article{Blagosklonny2001ExploitingCC,
  title={Exploiting cancer cell cycling for selective protection of normal cells.},
  author={Mikhail V. Blagosklonny and Arthur B. Pardee},
  journal={Cancer research},
  year={2001},
  volume={61 11},
  pages={4301-5}
}
Chemotherapy of cancer is limited by its toxicity to normal cells. On the basis of discoveries in signal transduction and cell cycle regulation, novel mechanism-based therapeutics are being developed. Although these cell cycle modulators were designed to target cancer cells, some of them can also be applied for a different purpose, i.e., to protect normal cells against the lethality of chemotherapy. Loss of sensitivity of cancer cells to cell cycle inhibitors can be exploited for selective… CONTINUE READING