Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

Abstract

Complement C3a is an important protein in innate and adaptive immunity, but its specific roles in vivo remain uncertain because C3a degrades rapidly to form the C3a-desArg protein, which does not bind to the C3a receptor and is indistinguishable from C3a using antibodies. Here we develop the most potent, stable and highly selective small molecule modulators… (More)
DOI: 10.1038/s41467-017-00414-w

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@inproceedings{Lohman2017ExploitingAN, title={Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a}, author={Rink-Jan Lohman and Johan K Hamidon and Robert C Reid and Jessica A Rowley and Mei-Kwan Yau and Maria A. Halili and Daniel S Nielsen and Junxian Lim and Kai-Chen Wu and Zhixuan Loh and Anh Tuan Do and Jacky Y. Suen and Abishek Iyer and David P. Fairlie}, booktitle={Nature communications}, year={2017} }