Exploiting a minimal system to study the epigenetic control of DNA replication: the interplay between transcription and replication

In order to analyze epigenetic factors involved in the regulation of DNA replication in higher eukaryotic cells, minimal systems have to be established. We have recently constructed a non-viral episomal vector system which replicates episomally in mammalian cells and is stably maintained in the cell in the absence of selection. The potential functional… CONTINUE READING