Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA.

@article{Zheng2009ExploitingAB,
  title={Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA.},
  author={Xiang Zheng and Ulysses W Sallum and Sarika Verma and Humra Athar and Conor L. Evans and Tayyaba Hasan},
  journal={Angewandte Chemie},
  year={2009},
  volume={48 12},
  pages={2148-51}
}
A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of beta-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards beta-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the beta-lactam ring) releases the phototoxic component from the prodrug (see picture; Q = quencher). 

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