Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems.

@article{Hilfinger2016ExploitingNF,
  title={Exploiting Natural Fluctuations to Identify Kinetic Mechanisms in Sparsely Characterized Systems.},
  author={Andreas Hilfinger and Thomas M Norman and Johan Paulsson},
  journal={Cell systems},
  year={2016},
  volume={2 4},
  pages={
          251-9
        }
}
From biochemistry to ecology, many biological systems are stochastic, complex, and sparsely characterized. In such systems, each component may respond to changes in any directly or indirectly connected components, thus requiring knowledge of the whole to predict the dynamics of the parts. Here, we address this challenge by deriving relations between properties of fluctuations that only reflect local interactions between a subset of components but are invariant to all indirectly connected… CONTINUE READING
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