Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer

@inproceedings{Sharbeen2015ExploitingBE,
  title={Exploiting Base Excision Repair to Improve Therapeutic Approaches for Pancreatic Cancer},
  author={George Sharbeen and Joshua Mccarroll and David Goldstein and Phoebe A. Phillips},
  booktitle={Front. Nutr.},
  year={2015}
}
Pancreatic ductal adenocarcinoma (PDA) is a highly chemoresistant and metastatic disease with a dismal 5-year survival rate of 6%. More effective therapeutic targets and approaches are urgently needed to tackle this devastating disease. The base excision repair (BER) pathway has been identified as a predictor of therapeutic response, prognostic factor, and therapeutic target in a variety of cancers. This review will discuss our current understanding of BER in PDA and its potential to improve… CONTINUE READING