Exploitation of the host cell ubiquitin machinery by microbial effector proteins.

@article{Lin2017ExploitationOT,
  title={Exploitation of the host cell ubiquitin machinery by microbial effector proteins.},
  author={Yi-Han Lin and Matthias P Machner},
  journal={Journal of cell science},
  year={2017},
  volume={130 12},
  pages={
          1985-1996
        }
}
Pathogenic bacteria are in a constant battle for survival with their host. In order to gain a competitive edge, they employ a variety of sophisticated strategies that allow them to modify conserved host cell processes in ways that favor bacterial survival and growth. Ubiquitylation, the covalent attachment of the small modifier ubiquitin to target proteins, is such a pathway. Ubiquitylation profoundly alters the fate of a myriad of cellular proteins by inducing changes in their stability or… CONTINUE READING
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