Exploitation of the folate receptor in the management of cancer and inflammatory disease.

@article{Leamon2008ExploitationOT,
  title={Exploitation of the folate receptor in the management of cancer and inflammatory disease.},
  author={Christopher P. Leamon and Ann L. Jackman},
  journal={Vitamins and hormones},
  year={2008},
  volume={79},
  pages={203-33}
}
Over the last 25+ years, the folate receptor (FR) has emerged as an attractive tumor biomarker with the potential to be exploited for therapeutic purposes. Increasing evidence suggests that this endocytosing protein can functionally mediate the cellular uptake and retention of natural folates, certain antifolates, and folate-drug conjugates; the consequences of the latter two events could result in biological modulation, including (but not limited to) tumor-targeted cytotoxicity. Because its… CONTINUE READING

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