Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence

  title={Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence},
  author={Pyong Woo Park and Gerald B Pier and Michael T. Hinkes and Merton R. Bernfield},
Cell-surface heparan sulphate proteoglycans (HSPGs) are ubiquitous and abundant receptors/co-receptors of extracellular ligands, including many microbes. Their role in microbial infections is poorly defined, however, because no cell-surface HSPG has been clearly connected to the pathogenesis of a particular microbe. We have previously shown that Pseudomonas aeruginosa, through its virulence factor LasA, enhances the in vitro shedding of syndecan-1—the predominant cell-surface HSPG of epithelia… CONTINUE READING


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