Exploitation of nucleic acid packaging signals to generate a novel influenza virus-based vector stably expressing two foreign genes.

@article{Watanabe2003ExploitationON,
  title={Exploitation of nucleic acid packaging signals to generate a novel influenza virus-based vector stably expressing two foreign genes.},
  author={Tokiko Watanabe and Shinji Watanabe and Takeshi Noda and Yutaka Fujii and Yoshihiro Kawaoka},
  journal={Journal of virology},
  year={2003},
  volume={77 19},
  pages={
          10575-83
        }
}
At the final step in viral replication, the viral genome must be incorporated into progeny virions, yet the genomic regions required for this process are largely unknown in RNA viruses, including influenza virus. Recently, it was reported that both ends of the neuraminidase (NA) coding region are critically important for incorporation of this vRNA segment into influenza virions (Y. Fujii, H. Goto, T. Watanabe, T. Yoshida, and Y. Kawaoka, Proc. Natl. Acad. Sci. USA 100:2002-2007, 2003). To… CONTINUE READING
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