Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis.

@article{Akkoyunlu2001ExploitationOI,
  title={Exploitation of interleukin-8-induced neutrophil chemotaxis by the agent of human granulocytic ehrlichiosis.},
  author={Mustafa Akkoyunlu and Stephen E. Malawista and Juan Anguita and Erol Fikrig},
  journal={Infection and immunity},
  year={2001},
  volume={69 9},
  pages={5577-88}
}
The agent of human granulocytic ehrlichiosis (HGE) is an obligate intracellular bacterium with a tropism for neutrophils; however, the mechanisms of bacterial dissemination are not yet understood. Interleukin-8 (IL-8) is a chemokine that induces neutrophil migration to sites of infection for host defense against pathogens. We now show that HGE bacteria, and the HGE-44 protein, induce IL-8 secretion in a promyelocytic (HL-60) cell line that has been differentiated along the neutrophil lineage… CONTINUE READING

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