Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery

  title={Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery},
  author={D Demers and Matthew A. Knestrick and Renee M. Fleeman and Rahmy Tawfik and Ala Azhari and Ashley Souza and Brian A. Vesely and Mandy Netherton and Rashmi Gupta and Beatrice L. Colon and Christopher A. Rice and Mario A. Rodr{\'i}guez-P{\'e}rez and Kyle H. Rohde and Dennis E. Kyle and Lindsey N. Shaw and Bill J. Baker},
  journal={Marine Drugs},
There is an acute need for new and effective agents to treat infectious diseases. We conducted a screening program to assess the potential of mangrove-derived endophytic fungi as a source of new antibiotics. Fungi cultured in the presence and absence of small molecule epigenetic modulators were screened against Mycobacterium tuberculosis and the ESKAPE panel of bacterial pathogens, as well as two eukaryotic infective agents, Leishmania donovani and Naegleria fowleri. By comparison of… 

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