Exploitation of Host Cell Biology and Evasion of Immunity by Francisella Tularensis

@inproceedings{Asare2010ExploitationOH,
  title={Exploitation of Host Cell Biology and Evasion of Immunity by Francisella Tularensis},
  author={Rexford Asare and Yousef Abu Kwaik},
  booktitle={Front. Microbio.},
  year={2010}
}
Francisella tularensis is an intracellular bacterium that infects humans and many small mammals. During infection, F. tularensis replicates predominantly in macrophages but also proliferate in other cell types. Entry into host cells is mediate by various receptors. Complement-opsonized F. tularensis enters into macrophages by looping phagocytosis. Uptake is mediated in part by Syk, which may activate actin rearrangement in the phagocytic cup resulting in the engulfment of F. tularensis in a… CONTINUE READING
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