Explicit Treatment of Non‐Michaelis‐Menten and Atypical Kinetics in Early Drug Discovery **

@article{Srinivasan2020ExplicitTO,
  title={Explicit Treatment of Non‐Michaelis‐Menten and Atypical Kinetics in Early Drug Discovery **},
  author={B. Srinivasan},
  journal={ChemMedChem},
  year={2020},
  volume={16}
}
Biological systems are highly regulated. They are also highly resistant to sudden perturbations enabling them to maintain the dynamic equilibrium essential to sustain life. This robustness is conferred by regulatory mechanisms that influence the activity of enzymes/proteins within their cellular context to adapt to changing environmental conditions. However, the initial rules governing the study of enzyme kinetics were mostly tested and implemented for cytosolic enzyme systems that were easy to… Expand

References

SHOWING 1-7 OF 7 REFERENCES
Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.
  • R. Copeland
  • Chemistry, Medicine
  • Methods of biochemical analysis
  • 2005
Kinetics of Enzyme Action: Essential Principles for Drug Hunters
Curr
  • Protoc. Pharmacol. 2016
  • 2016
Int
  • J. Genomics 2016
  • 2016
Segel in Encyclopaedia of Biological Chemistry
  • 2013
Wiley-VCH GmbH Wiley VCH Donnerstag
  • ChemMedChem
  • 2004
Accepted manuscript online