Explicit Tracking of Uncertainty Increases the Power of Quantitative Rule-of-Thumb Reasoning in Cell Biology

@article{Johnston2014ExplicitTO,
  title={Explicit Tracking of Uncertainty Increases the Power of Quantitative Rule-of-Thumb Reasoning in Cell Biology},
  author={Iain G. Johnston and Benjamin C Rickett and Nick S. Jones},
  journal={Biophysical Journal},
  year={2014},
  volume={107},
  pages={2612 - 2617}
}
Back-of-the-envelope or rule-of-thumb calculations involving rough estimates of quantities play a central scientific role in developing intuition about the structure and behavior of physical systems, for example in so-called Fermi problems in the physical sciences. Such calculations can be used to powerfully and quantitatively reason about biological systems, particularly at the interface between physics and biology. However, substantial uncertainties are often associated with values in cell… 
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