Explanation of Cocaine Desensitization of Blood Pressure Responses to Ephedrine

@article{Cannon1961ExplanationOC,
  title={Explanation of Cocaine Desensitization of Blood Pressure Responses to Ephedrine},
  author={Calvin Cannon and F F Cowan and Theodore Kopp{\'a}nyi and G D Maengwyn-Davies},
  journal={Science},
  year={1961},
  volume={134},
  pages={1075 - 1077}
}
  • Calvin Cannon, F F Cowan, +1 author G D Maengwyn-Davies
  • Published 1961
  • Medicine
  • Science
  • It is suggested that cocaine desensitizes ephedrine blood pressure responses by depletion of norepinephrine depots. This was shown by reversing cocaine desensitization through the administration of agents such as bretylium, which has a sparing effect on norepinephrine, and by the infusion of norepinephrine itself. 

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