Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients.

@article{Press2009ExplainingVI,
  title={Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients.},
  author={Rogier R. Press and Berend Arnold Ploeger and Jan D den Hartigh and Tahar van der Straaten and Johannes van Pelt and Meindert Danhof and Johan W. de Fijter and Henk-Jan Guchelaar},
  journal={Therapeutic drug monitoring},
  year={2009},
  volume={31 2},
  pages={187-97}
}
To prevent acute rejection episodes, it is important to reach adequate tacrolimus (TRL) exposure early after kidney transplantation. With a better understanding of the high variability in the pharmacokinetics of TRL, the starting dose can be individualized, resulting in a reduction in dose adjustments to obtain the target exposure. A population pharmacokinetic analysis was performed to estimate the effects of demographic factors, hematocrit, serum albumin concentration, prednisolone dose, TRL… CONTINUE READING
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