Explaining the effectiveness of fear extinction through latent-cause inference

  title={Explaining the effectiveness of fear extinction through latent-cause inference},
  author={Mingyu Song and Carolyn E. Jones and Marie H Monfils and Yael Niv},
  journal={Neurons, Behavior, Data analysis, and Theory},
Acquiring fear responses to predictors of aversive outcomes is crucial for survival. At the same time, it is important to be able to modify such associations when they are maladaptive, for instance in treating anxiety and trauma-related disorders. Standard extinction procedures can reduce fear temporarily, but with sufficient delay or with reminders of the aversive experience, fear often returns. The latent-cause inference framework explains the return of fear by presuming that animals learn a… 

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Building physiological toughness: Some aversive events during extinction may attenuate return of fear.
Shifting from fear to safety through deconditioning-update
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Context, learning, and extinction.
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Gradual extinction reduces reinstatement
The results suggest that the GE process is suitable for increasing the efficacy of fear extinction, and significantly reduced the return of fear in the reinstatement test for the startle response but not for SCR or contingency ratings.
Context and behavioral processes in extinction.
  • M. Bouton
  • Psychology, Biology
    Learning & memory
  • 2004
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Spacing extinction trials alleviates renewal and spontaneous recovery
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Reinstatement of fear to an extinguished conditioned stimulus.
  • R. Rescorla, C. Heth
  • Psychology, Biology
    Journal of experimental psychology. Animal behavior processes
  • 1975
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