Explaining the dynamics of tumor aggressiveness: At the crossroads between biology, artificial intelligence and complex systems.

@article{Porta2018ExplainingTD,
  title={Explaining the dynamics of tumor aggressiveness: At the crossroads between biology, artificial intelligence and complex systems.},
  author={Caterina A M La Porta and Stefano Zapperi},
  journal={Seminars in cancer biology},
  year={2018}
}
Facing metastasis is the most pressing challenge of cancer research. In this review, we discuss recent advances in understanding phenotypic plasticity of cancer cells, highlighting the kinetics of cancer stem cell and the role of the epithelial mesenchymal transition for metastasis. It appears that the tumor micro-environment plays a crucial role in… CONTINUE READING