Enhanced development of mouse single blastomeres into blastocysts via the simultaneous inhibition of TGF‐β and ERK pathways in microdroplet culture
- BiologyJournal of cellular biochemistry
It is found that BL development was improved in a lower volume of medium compared with a higher volume, and the supplementation of medium with the inhibitors of ERK1/2 and TGFβ signaling pathways in 1 µL droplets of T6 medium improved BL development.
Cell-cell communication through FGF4 generates and maintains robust proportions of differentiated cell types in embryonic stem cells
It is reported that the differentiation of robust proportions of epiblast-like and primitive endoderm-like cells in mouse embryonic stem cell cultures emerges at the population level through cell-cell communication via a short-range FGF4 signal.
Genomic insights into chromatin reprogramming to totipotency in embryos
- BiologyThe Journal of cell biology
Changes in DNA methylation, chromatin accessibility, and topological architecture occurring during the reprogramming to totipotency in the early embryo are discussed.
Investigating the role of the Hippo pathway member Nf2 in the segregation of trophectoderm and inner cell mass
It is shown that Nf2 is required in a cell-autonomous manner for the proper localization of Yap in inside cells of the embryo and demonstrated that this signaling is broadly required for the segregation of ICM from TE.
Developmental Plasticity Is Bound by Pluripotency and the Fgf and Wnt Signaling Pathways
- BiologyCell reports
Formation of distinct cell types in the mouse blastocyst.
- BiologyResults and problems in cell differentiation
These first cell fate decisions are described, how they can be biased whilst maintaining flexibility and, finally, some of the molecular circuitry underlying early fate choice are described.
TDP-43 safeguards the embryo genome from L1 retrotransposition
It is shown that TAR DNA binding protein 43 (TDP-43), mutations in which constitute a major risk factor for amyotrophic lateral sclerosis (ALS), inhibits L1 retrotransposition in mouse embryonic stem cells (mESCs) and preimplantation embryos and is identified as a guardian of the embryonic genome.
EVALUATION OF DEVELOPMENTAL CHARACTERISTICS OF SINGLE BLASTOMERE BIOPSIED FROM 8-CELL MOUSE EMBRYO DURING PREIMPLANTATION DEVELOPMENT
- BiologyBÁO CÁO KHOA HỌC VỀ NGHIÊN CỨU VÀ GIẢNG DẠY SINH HỌC Ở VIỆT NAM HỘI NGHỊ KHOA HỌC QUỐC GIA LẦN THỨ 5 - PROCEEDING OF THE 5TH NATIONAL SCIENTIFIC CONFERENCE ON BIOLOGICAL RESEARCH AND TEACHING IN VIETNAM
The results provide potential benefits for preimplantation genetic diagnosis (PGD) in infertile couples at risk of genetic diseases as well as opening a novel approach for the establishment of stem cell line from biopsied blastomere combined with PGD in future research.
A critical review on induced totipotent stem cells: types and methods
- BiologyStem Cell Research
Obox4 secures zygotic genome activation upon loss of Dux
It is reported that the multicopy mouse homeobox gene, Obox4, encodes a transcription factor that redundantly drives ZGA, and is identified as a pioneer factor that provides genetic redundancy to pre-implantation development.
SHOWING 1-5 OF 5 REFERENCES
Experiments on developing rats. II. The development of isolated blastomeres and fused eggs
Experiments on the transplantation of ova in mice; Badania nad transplantacją jaj myszy
Omowione zostaly dokladnie obie techniki oraz sposob postepowania z wyplukanymi jajami wydanie transplantacje jaj mysich 2-blastomerowych, 8- Blastocyst i blastocyst do macicy przez szyjke maciczną.