Experiments on the Carcinogenicity and Reactivity of β-propiolactone

  title={Experiments on the Carcinogenicity and Reactivity of $\beta$-propiolactone},
  author={C. E. Searle},
  journal={British Journal of Cancer},
  pages={804 - 811}
fi-PROPIOLACTONE (3-hydroxypropionic acid lactone, O.CH2.CH2C: O) is a highly reactive compound of simple structure which is now available in quantity. It has many possible uses as an organic synthetic agent, and has been recommended for sterilising plasma (Hartmann, LoGrippo and Kelly, 1954) and arterial grafts (Rains et al., 1956) and as a toxoiding agent in place of formalin (Orlans and Jones, 1958). It is therefore of importance that ,-propiolactone, besides being a vesi-cant, is also a… Expand
The fundamental mechanisms of in rdtro alkylation were reviewed before a conference of the New York Academy of Sciences in 1957.11*15 It was pointed out that alkylation may be regarded as theExpand
Tumor initiatory activity of some chloromononitrobenzenes and other compounds.
Treatment of mouse skin with pentachloronitrobenzene and each of the 3 tetrachloroacetone and β-bromopropionic acid, but not N -ethylmaleimide, also acted as tumor initiators and did not affect skin carcinogenesis in the mouse by benzo[ a ]. Expand
A number of N-alkylnitroso compounds have very potent biological actions, including acute cellular injury in the liver and other organs, carcinogenesis, mutagenesis, and teratogenesis. Aspects ofExpand
Studies of the reaction of β-propiolactone with deoxyguanosine and related compounds☆
Abstract The reaction of β-propiolactone with guanosine and related compounds was shown to give the previously reported product 7-(2-carboxyethyl)guanine, and a second product which was characterizedExpand
Reactions of beta-propiolactone with nucleobase analogues, nucleosides, and peptides: implications for the inactivation of viruses.
The study determined the reactivity of β-propiolactone with nucleobase analogues, nucleosides, and amino acid residues and elucidated the chemical structures of the reaction products. Expand
Chromatography of alkylating agents. II. Nitrosamines, epoxides, lactones, methanesulfonates and miscellaneous derivatives.
Particular stress was placed on the salient role of chromatographic procedures in the elaboration of compound homogeneity, metabolism, degradation and mode of action of these agents, with particular relevance to the environmental aspects. Expand
The relevance of preclinical assessment of carcinogenesis
  • F. Roe
  • Medicine
  • Clinical pharmacology and therapeutics
  • 1966
It is suggested that the following have a high carcinogenicity rating: biological alkylating agents, urethan, isonicotinic acid hydrazide (INAH), arsenic, coal tar and creosote preparations, phenylbutazone, estrogens, large implants of materials in the course of plastic or reconstruction surgery, and combinations of 131I with goitrogens. Expand
Drugs with Lactone Groups as Potential Carcinogens
One of the most valuable features in the extension of our knowledge of carcinogens to include new types is the possible application of such work to the development of protective measures. This isExpand
Chromatography of alkylating agents. I. Aziridines, nitrogen and sulfur mustards and related derivatives.
Abstract We have attempted to stress the major areas of diverse chromatographic procedures for the analyses of a broad spectrum of alkylating agents and related derivatives. Chromatographic analysesExpand
An evaluation of skin painting studies as determinants of tumorigenesis potential following skin contact with carcinogens.
Data in the literature indicate that animal skin painting tests, performed according to current protocols, cannot be conclusively relied upon to determine the potential carcinogenicity of applied chemicals. Expand


Organic Chemistry:
THIS book claims to cover the organic chemistry required by second-year medical students and by students reading for a general B.Sc. degree ; the claim is not exaggerated. The wants of the former areExpand
Practical Organic Chemistry
IF one were to try to find any cause for adverse criticism of this excellent book, it would be that it fails to suggest to the student the need for reading the original literature on the subject, andExpand
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