Experimentally observed conformation-dependent geometry and hidden strain in proteins.

  title={Experimentally observed conformation-dependent geometry and hidden strain in proteins.},
  author={P. Andrew Karplus},
  journal={Protein science : a publication of the Protein Society},
  volume={5 7},
A database has been compiled documenting the peptide conformations and geometries from 70 diverse proteins refined at 1.75 A or better. Analysis of the well-ordered residues within the database shows phi, psi-distributions that have more fine structure than is generally observed. Also, clear evidence is presented that the peptide covalent geometry depends on conformation, with the interpeptide N-C alpha-C bond angle varying by nearly +/-5 degrees from its standard value. The observed deviations… CONTINUE READING

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